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" ... Mutant mitochondria are purged by selection among cell lineages, especially via a population bottleneck that occurs during early development. In mice (and likely other mammals as well), for a few days after fertilization, the zygote’s cells divide, but mitochondria do not. So each cell ends up with a small subset of the mitochondria that were present in the zygote. It’s believed these cells then compete metabolically; those that have a relatively high proportion of mutant mitochondria are mostly eliminated because they are unable to generate energy efficiently. ... "