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" ... While these results are interesting from a scientific standpoint, it will be very challenging for ALKS-3831 to become a successful drug. First of all, the difference in weight gain between the two regimens in the Alkermes trial wasn’t dramatic. In fact, my guess is that if Alkermes used a different antipsychotic such as ziprasidone, which doesn’t cause as much weight gain, the differences would be minimal. But the bigger question is whether the benefit of less weight gain with ALKS-3831 will be worth the higher expected cost of this drug compared to generic olanzepine. It is questionable that payers would be willing to pay a premium for ALKS-3831 for the benefit of a few less pounds gained by a patient. ... "