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" ... But, the U.K.’s announcement this past Saturday raises more questions than answers; about increased transmission risk, virulence of the new variant, impact on treatment and vaccine efficacy, and direct policy implications, such as travel restrictions, in the near term. ... "
" ... Further research from the San Fransisco study indicates increased virulence as well. Aligning with the observation of increased viral load, researchers found a 21% increase in ICU admissions and an eleven times increase in death among those contracting B.1.427/429. ... "
" ... This variant has all the characteristics which we associate with viruses that are more transmissible, capable of antibody resistance, and potential for increased virulence and replication. The observation that this variant has spread from West Africa to other nations around the world is yet another warning that we are likely to be inundated by a deluge of variants, not only homegrown but from all over the world. It is going to take a massive sustained effort to understand the implications of this and other variants for both the future of the pandemic and vaccine design. ... "
" ... While the authors of this research focus on transmissibility, it may also go a long way to understand virulence. Those that are infected with B.1.1.7 have a higher probability of dying from the infection. Spike protein mutations like those found in B.1.1.7 increase transmissibility by increasing affinity to the human ACE2 receptor. That may not be the whole story. During the extended period of time B.1.1.7 survives within the host, it must fend off the immune system. SARS-CoV-2 specifies immune modulators like ORF3a, ORF8, and others. These may be altered during the virus’s extended stay, resulting in greater virulence and chance of death. ... "