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" ... Committee members seemed less disturbed this time around about the issues that concerned them at the earlier meeting. The theoretical risk of an increase in cancer was discussed at length but did not appear to bother the panel. Valvulopathy and cardiovascular adverse events were the major obstacles. For valvulopathy, although the data from Arena did not allow the FDA reviewers to rule out an increased relative risk of 1.5 with lorcaserin, the absolute incidence of valve problems was low. A few panel members raised the idea of requiring echocardiograms prior to prescribing lorcaserin. ... "