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" ... The virus that helped protect people in Philadelphia against smallpox during and after the Civil War turns out to be closely related to the modern vaccinia virus: a milder relative of smallpox. ... "
" ... Vaccinia is not one of the safer vaccines. In people with defective immune systems, the normally mild infection can be severe, so eradicating smallpox not only saved people from smallpox but from needing the vaccine (it is still used in specialized settings such as the military). But vaccinia has not outlived its usefulness. ... "