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" ... But the modeling study still serves as a dire warning—to vaccine developers, policymakers, and anyone who thinks this initial wave of vaccinations will be enough to protect us from the virus for the remainder of 2021. If we don’t reconfigure our vaccine strategies to address the discrepancies between vaccines and their reduced potency over time and against the variants—especially that of the adenovirus vaccines—we risk leaving some vaccinees more vulnerable than others for no reason other than negligence and complacency. For as hopeful as it is that many of us will be vaccinated by the end of this year, if we don’t look to the future, we risk ending up back where we started: isolated, unprotected, and wondering why our public health leaders didn’t act sooner. ... "
" ... Though further confirmation that the Moderna and Pfizer-BioNTech vaccines generate a robust immune response is always welcome, when new variants are thrown into the mix the results are less promising. Researchers investigated this particular piece of the puzzle by pitting antibody-loaded plasma from the vaccinees against lab-generated SARS-CoV-2 spike proteins containing some of the defining mutations of emergent variants, including N501Y, K417N, and E484K (Figure 1). All three of these mutations appear either singularly or simultaneously in the B.1.1.7 (UK), B.1.351 (South Africa), and P.1 (Brazil) variants, and all three are either suspected or known to play a role in increasing chances of immune evasion and person-to-person transmission. ... "