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" ... Cherry and her team treated respiratory cells with diABZI and observed that it induced expression of more than 400 genes, nearly 40 percent of which link back to interferon signaling pathways. Compared to cells treated with interferon beta, upregulation of interferon-stimulated genes in diABZI-treated cells was more transient—meaning the risk of overstimulation is much less. Despite differences in duration, diABZI still suppressed the virus at a potency comparable to type I interferon treatment, blocking SARS-CoV-2 replication about 1000-fold in air-liquid interface cultures. ... "
" ... The best example I can think of for that therapeutic approach is tanezumab/fasinumbar—both antibodies that target Nerve Growth Factor, a hormone that can cause upregulation of TrpV1 receptors and other ion channels that increase excitability and can result in chronic pain: ... "
" ... The initial concerns arose over the mechanism by which NSAIDs could theoretically be of harm in Covid-19 patients—namely the upregulation of angiotensin-converting enzyme 2 (ACE2) receptors located in the lungs, kidney, arteries, heart and intestines, and used by SARS-CoV-2 as the key entry point into cells. The other concern was that NSAIDs could potentially delay or interfere with diagnosis of Covid-19 by masking fever and resulting inflammation. ... "