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" ... There are, of course, genetic constraints that work against hybrid speciation in animals. The most persistent hybrid species possess the same number of chromosomes as both parental species. This means both parental species must be closely related to avoid genetic and developmental problems associated with unpaired chromosomes in their hybrid offspring. This form of hybridization, known as homoploid hybrid speciation, is most common amongst animals. (The most famous mammalian hybrid, the mule, is the product of a horse and a donkey, which have different numbers of chromosomes, thus rendering their hybrids infertile.) ... "