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" ... 4. Protection of viral proteins from degradation. Modification of proteins by the addition of either ADP-ribose or ubiquitin marks the modified protein for degradation by cellular enzymes. One domain of the NSP3 removes ADP-ribose from modified viral proteins and others de-ubiquitinate marked proteins. ... "
" ... Indeed, additional work showed that the VHL genes produce proteins that then help connect ubiquitin to HIF-1α and thus label HIF-1α for destruction. In essence, VHL is like a warehouse inventory manager using ubiquitin as a label for “get rid of this.” But the scientists were still left with the question, how do oxygen levels influence whether VHL labels HIF-1α with ubiquitin? ... "