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" ... Bladder tumors are typically shielded from the immune system, meaning that it cannot intervene and attack the cancer, commonly referred to in medicine as (immune) "cold" tumors. The researchers suspect that CVA21 treatment causes inflammation within the tumor cells, leading to an influx of immune cells which are piqued to kill the cancer cells, making the tumors "hot". ... "
" ... CAR T-cells are already approved for some types of blood cancer and have achieved long-term survival for many patients who had otherwise run out of treatment options. However, despite early hype, they have yet to really make much of an impact on the treatment of solid tumors. So how has the technology improved in recent years to allow for trials like these in DIPG/DMG? ... "
" ... Ilovitsh explained that this immune reaction was more effective than they initially thought it would be. “Our mice had tumors on both sides of their bodies. Despite the fact that we conducted the treatment only on one side, the immune system attacked the distant side as well.” ... "
" ... The paper highlights the candidate’s ability to target and shrink HPV motivated tumors in both animal studies and human blood samples. ... "
" ... These Th17 and Th1 cells, types of T-cells, are part of an orchestra of multiple, complex parts which if perfectly conducted can mount an immune response against tumors. TGF-β in this case is a protein called a growth factor, which causes an overproduction of Th17 cells rather than Th1, meaning that the correct cells to trigger an immune response after immune checkpoint therapies are simply not present in the bone tumors. ... "