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" ... In contrast to the detection of a single genetic alteration, NGS aims to record genetic alterations present across diverse cancer subtypes. Moreover, NGS can detect several mutations that could be responsible for driving tumorigenesis and identify resistance mechanisms that may have evolved from pre-existing clones after treatment. As Professor Nicola Normanno, Director of Translational Research Department of the Istituto Nazionale Tumori in Naples, Italy says “ctDNA detection by liquid biopsy is useful, and with the NGS platform, we would be able to obtain a more in-depth molecular characterization of the tumor.” But in a study of NGS liquid biopsy, he and his team highlighted some of the challenges they need to address. “The central point from our study is that we need to work more on specificity and sensitivity to move NGS liquid biopsy into the clinic. This is due to the low level of ctDNA in blood samples but also due to potential artifacts detected by NGS which are from clonal hematopoiesis rather than from tumor-associated DNA. So, we need to understand more about the biology of ctDNA in order to improve the technology.” ... "