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" ... As archaeological excavation and diagnosis of ancient human remains gets more accurate and more efficient, the antiquity and evolution of diseases such as the treponematoses (pinta, yaws, bejel, and venereal syphilis) will eventually become clearer. The analysis of even isolated skulls such as this one from the Wilhoite site in Tennessee can therefore contribute to a broader understanding of disease transmission in the pre-Columbian world. ... "