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" ... Efraim's quote from his book appears widely in discussions of DNP as a toxic fat burner: "Unfortunately in some cases, the treatment eliminated not only the fat but also the patients, and several fatalities were reported [in JAMA]. This discouraged physicians for awhile until they discovered that high doses of thyroxine resulted in weight loss. This was used for some time in the early 1930's until some more obituaries appeared." ... "