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" ... In an accompanying editorial, Joshua Beckman writes that "the net clinical benefit of thrombolysis suggests evidence of modest efficacy for thrombolysis in intermediate-risk PE, rendering the need for decision making on a patient-by-patient basis." ... "
" ... In recent years, catheter-directed thrombolysis (CDT) has been added to the current standard of anticoagulation therapy in some patients with deep vein thrombosis (DVT). The hope was that CDT would help reduce the high rate of post-thrombotic syndrome (PTS), but now an observational study finds no benefits and some important disadvantages associated with CDT. ... "
" ... Over the past few years, Visionable has been working with the NHS East of England Stroke Telemedicine Partnership to improve the delivery of stroke diagnosis and treatment. Lowe explains: “Using Visionable’s advanced video collaboration and imaging technology, the NHS East of England Stroke Telemedicine Partnership team has helped a number of patients be assessed, with an average of 41% receiving thrombolysis. This means that health practitioners have been able to work more efficiently, and patients receive faster and better treatment. Treatment time has also been reduced by 48 minutes.” ... "
" ... The SWIFT trial studied 196 patients receiving thrombolysis for confirmed large vessel anterior circulation occlusions within 6 hours of the onset of symptoms. Following randomization half received additional endovascular therapy with the Solitaire device. Functional independence, defined as a score under 2 on the modified Rankin scale, was achieved in 60.2% in the treatment group and 35.5% in the control group (p=0.0008). There was no significant difference in mortality at 90 days (9.2% versus 12.4%, p=0.50). ... "
" ... The chief disadvantage to thrombolysis was an early and significant increase in intracranial hemorrhage (fatal ICH at 1 week: 2·7% vs 0·4%). This resulted in a significant increase in early mortality, but this difference was no longer significant at 90 days, though a trend remained (17.9% versus 16.5%, HR 1.11, CI 0.99–1.25, p=0·07) ... "