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" ... In an ACC press release, lead investigator David Morrow said: "In the lab, we have seen very compelling science showing the importance of thrombin's action on platelets causing blood clots in arteries. This is the first study to show definitively that blocking this pathway reduces the risk of suffering another cardiovascular event." ... "
" ... The novel antiplatelet vorapaxar, which blocks the thrombin receptor to inhibit platelet activation, ran into trouble in the TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) trial, which was stopped prematurely earlier this year due to safety concerns. ... "
" ... Veltri also had been running the development of another Schering-invented drug, the thrombin receptor antagonist vorapaxar. This is widely viewed as the biggest potential hit in the pipeline of the combined companies. Analyst Catherine Arnold of Credit Suisse forecasts that vorapaxar could have annual sales of $2.1 billion in 2015 if it gets approved. The handling of this project has been passed to Veltri's lieutenant, John Strony. ... "