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" ... At first blush, oncology looks like the most obvious exception to this hypothesis, and seems like a discipline where precise subtyping and identification of unique drivers has truly revolutionized the field, leading to relatively specific treatments that target specific “driver” genes and pathways. Yet, Kathiresan and Khera suggest that immune-oncology research may prove “potentially even more influential.” Immunotherapy, they argue, was born from “recognition of a key causal pathway,” and is “largely agnostic to the specific driver mutation of an individual cancer cell,” and thus may “have utility across a broad range of cancer subtypes.” ... "