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" ... A leading critic says that the FDA has been remiss for not removing a stent from the market although strong evidence exists that its use leads to more deaths and strokes. ... "
" ... Broderick also praises CMS for refusing to provide reimbursement for the Wingspan stent outside of its use in a randomized trial, thereby encouraging enrollment in SAMMPRIS. “The FDA and CMS must be consistent gatekeepers for the distribution and diffusion into clinical practice of technology that affects the quality and cost of clinical care,” he concludes. ... "
" ... The 32 studies included 42,016 patients reporting 3,545 CVD events, 579 stent thromboses, and 1,413 bleeding events. Six studies were randomized trials (“effect-modification” design) and the remaining 26 reported individuals exposed to clopidogrel (“treatment-only” design). In treatment-only analysis, individuals with 1 or more CYP2C19 alleles (an alternative form of a gene) associated with lower enzyme activity had lower levels of active clopidogrel metabolites, less platelet inhibition, lower risk of bleeding, and higher risk of CVD events. However, there was evidence of small-study bias, the authors write. When analyses were restricted to studies with 200 or more events, the point estimate was lessened. ... "
" ... The key now for people who have suffered heart attacks is recovery and risk reduction. The heart attack need not be a harbinger of future health problems given the ample strategies available to reduce risk. For behaviors, it is important to be active, seek weight control, eat a healthy diet and get good sleep—and take the key medications. Regarding these medications, there are many options to consider to optimize and individualize each person’s approach, starting with statins. For those with a stent it is particularly important to take the pills that will help keep the stent open. ... "
" ... The kinds of things that U.S. companies are doing in India or Indian companies are doing in the U.S., the narrative of that often gets lost because we're focused on numbers, on problems and in that we often forget to talk about the successes. If the largest numbers of cardiologists trained in stent procedures is being done as a result of the massive scale up of training that Abbot and Boston Scientific are doing, that's an important thing to talk about because that's having a transformational impact in terms of patient outcomes. This is true for every sector. Infosys is revolutionizing the way we talk about upskilling in America, in helping bring talent into the tech field that are coming out of non-technology background. Infosys is putting skilling centers in universities and community colleges around the country--in Indiana, in Rhode Island, in Connecticut, in South Carolina, it's really making an impact. We want to be able to talk about those things as well. ... "