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" ... But until the 1950s, that minty clean feeling was mostly just a feeling. There was little evidence that toothpaste actually did what it promised: prevent cavities and improve oral health. It was not until 1955, when Proctor & Gamble added stannous fluoride to its Crest-brand toothpaste – after a decade of dental research at the University of Indiana – that toothpaste could claim to be clinically proven to combat decay. Other manufacturers soon followed suit, adding fluoride and other scientifically proven ingredients to fight against cavities, gum disease, and tartar. ... "