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" ... For the cells whose expression levels upon the first sorting lay in the middle five percent and highest five percent groups, the researchers observed no significant expression-level changes over the course of those seven days. The team wasn’t surprised that the cells whose GAL network expression level was in the middle five percent didn’t, after sorting, drift towards average expression levels. Those cells were already expressing at an average level. Neither were the researchers surprised that the cells sorted for the highest expression level did not, after sorting, express at an even higher level; the team attributed the lack of expression change to the likelihood that the GAL network activity would not be physiologically capable of reaching a higher level. Acar and his team were impressed, however, that yeast cells that were sorted for the lowest GAL network activity continued to display expression reduction, and they did so even after the sorting had stopped. (Acar considered the sorting itself to be the Darwinian selection pressure.) ... "
" ... The assumption of change management. The volatile, uncertain, complex and ambiguous (VUCA) world and the steady march of technologies necessitate the need for newer sales models and continuous innovation in customer and ecosystem engagement. As an example, at least in the software industry, the need for a shift from license management to lifecycle management is significant. ... "