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" ... Sigmoidoscopy Approach. Two of these swap having a colonoscopy every decade in favor of the less invasive sigmoidoscopy but supplementing this with either an annual gFOBT or FIT. Since both require annual trips to the doctor to provide a stool sample, I’d be indifferent which to use, especially since they each achieve nearly identical results in terms of life-years gained. Admittedly, the prep is less unpleasant than for a colonoscopy, but in my book, the burden of having to make ten trips to the doctor every decade easily offsets whatever discomfort is associated with a colonoscopy. In addition, over the next decade, I would lose anywhere from 3.7 to 7.0 days of life expectancy by relying on these tests rather than colonoscopy [1]. In short, if these were the only choices, it would be easy for me to choose a colonoscopy without much further thought. ... "