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" ... Maternal deaths among women with sickle cell disease are quite common, Oppong said. “Without modern care, the death rate could be as high as 20%,” he suggested. (Most published reports indicate a maternal mortality rate closer to 10%; the rate in regions without modern medical facilities is unknown.) Women with sickling hemoglobin are prone to develop severe vascular, heart and lung problems during pregnancy, Oppong explained. “They’re already anemic,” Oppong considered. “With the slightest amount of blood loss, the impact tends to be more severe. They may also develop hypertension in pregnancy, and that can have a profound effect.” ... "