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" ... Lingering safety doubts persist after several high-profile withdrawals, including the combination drug fenfluramine/phentermine in 1997, Meridia (sibutramine) in 2010, and Belviq (lorcaserin) in early 2020. Other once promising weight loss drugs, such as Acomplia (rimonabant), failed to gain U.S. approval due to safety concerns. ... "