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" ... PLX5622 is one of several drugs currently in clinical trials which are a class of 'CSF1R inhibitors' that is, they target microglia. Over forty trials of CSF1R inhibitors are in progress for everything from cancer to rheumatological diseases. None are yet FDA-approved. ... "
" ... This concern, in turn, influenced healthcare providers’ decision to treat fever or pain with NSAIDS, with many choosing to avoid NSAIDS, and use acetaminophen (Tylenol) instead. Much debate has since swirled around this topic, with currently available evidence pointing to no increased risk associated with use of NSAIDS—especially in patients already taking them for chronic rheumatological conditions such as osteoarthritis and rheumatoid arthritis. ... "