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" ... Melo saw an opportunity. His team initially was reluctant to work on complicated sweetener molecules like rebaudioside M (Reb-M), one of the super-sweet steviol glucosides in the stevia plant. This Reb-M molecule is only present in low concentrations (less than 2%) in the stevia plant, and it is difficult to isolate. But the Amyris scientists developed a unique method of making Reb-M using fermentation, the basic process we use to make beer, wine, and bread. By using a yeast culture to ferment sustainably-sourced sugarcane, Amyris was able to make very pure, sustainable Reb-M. ... "