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" ... Animal bite infections are commonly treated with a penicillin type of antibiotic (often Augmentin (amoxicillin-clavulanate). Patients who are allergic to penicillin might receive doxycycline, a quinolone, or TMP-SMX (Bactrim or Septra) instead. Keflex (cephalexin) and Clindamycin are not effective substitutes for treating Pasteurella, though often used in other types of skin infections. ... "
" ... I have long had severe reservations about quinolone antibiotics, like Levaquin and Cipro. I have had these concerns since I conducted clinical trials to test new antibiotics (including a variety of quinolones) before they went to market. Now I have further concerns about them because of their overuse as an alternative to busy physicians trying to puzzle out what’s wrong with the patient, and because practice “guidelines” promote their overuse. ... "
" ... The new trend is to treat with antibiotics alone, especially in Europe. Unfortunately, up to 37% of patients randomly assigned to this treatment in studies have needed an appendectomy in less than a year. Dr. Flum notes a typical treatment option is 48 hours of IV antibiotics followed by a week of oral Ciprofloxacin, a quinolone antibiotic, and Flagyl (metronidazole). The author makes an excellent point that experience with antibiotic therapy alone may not be this good outside of studies, as patients may not adhere to the full course of treatment, especially as both of these antibiotics often cause nausea. He also notes that cost analyses fail to account for cost of caregiver support and potential complications, focusing mostly on initial surgery. ... "