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" ... AGEP is a much less serious, and is characterized by the rapid eruption of red skin with small pustules within 2 days of exposure to the medication (blisters filled with yellow and white fluid). AGEP typically begins in the face, armpits or groin then spreads throughout the body. AGEP may be associated with fever and generalized malaise, but patients do not appear to be ill. The rash lasts for 1-2 weeks, as the skin peels of and resolution occurs. Treatment is supportive and may include oral antihistamines, moisturizers, and topical steroids until the rash clears. ... "
" ... In these pre-vaccination days, smallpox pustules would be lanced, and their contents inserted into the skin of healthy people, producing a (hopefully) minor, localized infection which would then protect people from severe smallpox infection. Smallpox inoculation saved many lives but was not without risk. Later in the century, Edward Jenner developed the practice that ultimately replaced it: vaccination. This practice was based on the observation that milkmaids previously infected with cowpox ("vaccinia"), a usually-minor infection in humans, were relatively safe from smallpox. Two hundred years later, smallpox was gone. ... "