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" ... At first glance, it might appear these studies are at odds, examining two distinct variants with two distinct methods. The first also directly involves a vaccine, while the second doesn’t. But both get at the same fundamental question—whether new variants of SARS-CoV-2 are adapting more rapidly to us than we are to them. They also have the same fundamental limitation, which is being confined to the laboratory. The first uses a pseudotype virus; the second, lab-cultured tissue. Excellent substitutes, in other words, but not the real thing. ... "
" ... The antibodies were next exposed to the linear epitopes and examined their ability to neutralize a pseudotype virus. Their samples indicated that 0% to 59% of the neutralization activity present in patient plasma is directed at non-receptor-binding domain epitopes. After depleting the neutralizing antibodies targeting the receptor-binding domain, the researchers found that non-receptor-binding domain antibodies, while not completely responsible for virus neutralization in patients, are at least partially responsible for residual neutralization, and are therefore important to the neutralization process. ... "