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" ... --Because prasugrel was administered only after PCI had been planned, the writing group "does not recommend that prasugrel be administered routinely to patients with UA/NSTEMI before angiography." ... "
" ... Notably, retrospective genetic studies showed that prasugrel and ticagrelor were unaffected by the CYP2C19*2 allele. Prospective identification of CYP2C19*2 carrier status might allow personalisation of dual antiplatelet treatment after PCI that successfully minimises major adverse cardiovascular events and adverse bleeding events. ... "
" ... One official, Thomas Marciniak, contends that ARBs may increase the risk of cancer. Marciniak has been a vocal critic of FDA's efforts to assess drug safety. In the past he has raised questions about other major drugs, including prasugrel, rosiglitazone, and rivaroxaban. But Marciniak's boss, Ellis Unger, who is the acting director of the office of new drugs, told the WSJ that Marciniak's concerns are a "diversion." ... "
" ... Other drugs have suffered from more hype. A couple years ago Eli Lilly made bold claims about prasugrel, the blood-thinner the company developed with Daiichi Sankyo. Like vorapaxar, prasugrel was supposed to be a way to grab a chunk of the $9-billion a year in sales Sanofi-Aventis and Bristol-Myers Squibb rake in from the blood thinner Plavix.Unlike vorapaxar, which is given in addition to Plavix, prasugrel is a Plavix competitor. ... "