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" ... Gram-negative bacteria are among the most worrisome in medicine today because of the limited antibiotics against them. Spero believes its potentiators could clear a way for whole classes of existing antibiotics against gram-positive bacteria, like macrolides, to start working against tough gram-negative bugs as Pseudomonas aeruginosa, acinetobacter baumannii, and E. coli. Pseudomonas, in particular, is one that’s common and a troublemaker that leads to ventilator-associated pneumonia. ... "