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" ... The FAB fragments of 92 monoclonal antibodies isolated from the four patients were added to an IgG1 framework. They then screened the 92 antibodies for polyreactivity, nonspecific binding to unrelated antigens, testing for binding to single-stranded DNA, double-stranded DNA, insulin, bacterial lipopolysaccharide, and streptavidin-APC. They found that 11 of the 92 monoclonal antibodies showed reactivity against two or more of the listed antigens. These were eliminated from future consideration. ... "