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" ... Koprowski, Sabin, and Salk all came up with different ways to prod the human immune system into setting up defenses against the polio virus. Today, the research teams working on SARS-CoV-2 vaccines are using genetic codes or proteins, rather than dead or weakened viruses, but each team is working a slightly different angle. Inovio’s candidate uses a specially engineered loop of DNA called a plasmid to manipulate the human immune system into producing antibodies against SARS-CoV-2. Moderna’s version uses messenger RNA, the molecule that transcribes the genetic code from DNA. Dozens of other research groups are working on their own methods. ... "
" ... Manufactured through a completely synthetic process in a cell-free environment, dbDNA is a linear, double-stranded DNA vector. Producing dbDNA is much faster than producing plasmid DNA, taking weeks instead of months. Additionally, the equipment to make dbDNA has a smaller manufacturing footprint than plasmids, so companies can more easily scale production. ... "