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" ... There are two more big challenges with today’s phosphoramidite synthesis. First, it produces significant volumes of toxic chemical waste. Second, it often requires post-synthesis purification and processing. ... "
" ... Today’s DNA makers still create their products using chemistry. To form a new double helix, the individual letters of DNA — nicknamed A, T, C and G — are linked together using a process called phosphoramidite synthesis. Though the process has been refined over the years, it still requires harsh solvents that limit the quality of the final product. These solvents also become noxious waste. ... "