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" ... I think that gradually, the collection of enormous amounts of data will help us more precisely define disease states that are currently waste basket collections of phenotypically similar but pathologically distinct entities — particularly in neuropsych, where we have nothing better than “I know it when I see it.” There may be a particular set of digital variables whose patterns differentiate one entity from another (similar to the arguments one heard a few years ago about gene expression signatures derived from testing circulating mRNA’s with ligand libraries of thousands of ligands). ... "