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" ... Keytruda (pembrolizumab), made by Merck & Co., is the drug that former President Jimmy Carter took after doctors discovered that melanoma had metastasized to his liver and brain. After just months of treatment, which included surgery, radiation and immunotherapy, doctors saw no signs of the disease. ... "
" ... Keytruda (pembrolizumab) works by blocking what’s known as the PD-1 pathway, which is a mechanism by which cancer cells evade detection by the T cells in the immune system that would normally eradicate them. By blocking PD-1, Keytruda unleashes the immune cells, which can then travel throughout the body, attacking cancer wherever it may be hiding. Sales of the drug hit $192 million in the first half of this year, and some analysts are predicting it will be a $5-billion-a-year blockbuster by 2018. ... "
" ... This is partly underpinned by other trials showing that DNA repair deficient tumors of different types, for example, bowel cancers do respond well to immunotherapy. In addition, de Bono and colleagues will be publishing more research over the coming months which provides evidence for this link between DNA repair deficient tumors and response to pembrolizumab. ... "