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" ... The inconsistency in the clinical results between different studies may be explained by the fact that: (i) the type of virus causing the common cold may have varied in each study and; (ii) the type of zinc formulation that was studied also varied. Different formulations use different types of additives such as flavoring agents and sugars which are commonly used to help improve the palatability of the zinc ions. In some formulations, these additives form highly bound complexes with the zinc ions. This results in poor ionic zinc availability. Given the link between ionic zinc availability and prevention of cold virus replication, it is only logical that decreased ionic Zinc availability may lead to decreased efficacy observed in some particular clinical studies. Effective delivery of the Zinc ions in the oral cavity is critical to the success of zinc formulations reducing the duration of the common cold caused by rhinovirus. There are many forms of Zinc supplements which do not release the Zinc ions in the oral cavity. This is likely to be a major reason for the inconsistent results in some zinc studies. ... "