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" ... Third, a well-timed M&A exit can lock in an enormous amount of value when the road to drug launches is long, costly, and fraught with volatility. Nine of the top 15 value creators since IPO were acquired. Given the challenge of developing new medicines, finding great partners through M&A can be hugely helpful beyond the immediate value realization. For example, consider the post-acquisition speed bumps that Kite and Juno have had in developing and launching CART products, or Receptos’ ozanimod FDA hurdles, or AveXis’s data integrity issues. Because they were in the hands of well-capitalized, capable partners, those products are all now delivering value for patients while growing revenues (or are on their way to). Through the acquisitions, value was crystallized for the shareholders, while greatly reducing their exposure to the volatility and dilution that would have been required to get through those speed bumps - while ensuring their drugs would have a well-resourced global sponsor to bring them to market. In short, the outsized role of M&A in capturing significant value during this IPO super-cycle is very clear in these data. ... "