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" ... In addition to these concerns, I also found myself increasing worried about the overinterpretation of data; in a number of talks, it seemed that two experimental conditions might be compared using a tool that generates huge amounts of data, such as whole genome sequencing or broad transcriptomic data, and a narrative would be generated around select molecules that were identified by the analysis. It felt a lot like a reprise of the experience of some of the early gene chip studies, which used a very similar approach, and generated a number of specious findings; as it happens, motivated researchers can generate an engaging narrative around most any small collection of random genes or proteins, and we most avoid seduction. ... "
" ... The concerning side is getting a little too far ahead of the scientific evidence for the role of certain genomic variants in health and disease. I always worry a little bit about the overinterpretation of the health information. But the horse is out of the barn, you're not going to stop it. My attitude is we just need the scientific community to catch up. The more we get that validity associated with the role of genomic variants to disease, the more that we don't have to worry about people being misled. I think of this as a short-term problem. ... "