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" ... At the same time, I think if our goal is to take a patient's tumor, sequence it, find the genes that are mutated, the pathways that are hyperactive, the genes that are overexpressed and then set up precision regimen to target those particular pathways based on that particular patient's genomic profile, if we want to get to that ideal, we want to have a really, really good understanding of what drugs that you're giving to cancer patients are doing. And if drugs are entering clinical trials with a kind of murky multifaceted action, I think that that holds us back from that precision medicine ideal. So, I do think that target validation and understanding mechanisms of action is very, very important when moving towards that goal. ... "