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" ... I hope that <the investigators>…have finally put to rest the question of whether PSA screening reduces prostate cancer mortality. I say this not to close debate but to refocus it. Screening with PSA testing does good by saving lives, but it also causes harm in terms of overdiagnosis and overtreatment. Thus, we need to determine how to screen so that the benefits outweigh the harms. ... "
" ... Lewis analyzes Nebraska’s cancer screening program, a widely touted success story that won a national award as the best wellness program in the country. From Lewis’ calculations, at least 6 percent, and as many as 15 percent, of screened participants were found to have signs of metastatic cancer. An epidemiologist would suggest this number is about 100 times too high – meaning thousands of Nebraskans received false-positives in this screening program. “My colleagues and I were concerned enough about this epidemiological arithmetic to telephone the state’s designated wellness program point person…” explains Lewis, “They in return were concerned enough about this statistically certain overdiagnosis on their employees not to call us back.” ... "
" ... On the other hand, screening mammograms do lead to overdiagnosis of breast cancer, acknowledged Brawley, whose editorial was entitled "Accepting the Existence of Breast Cancer Overdiagnosis." ... "