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" ... It turned out that fructose produced a lower rise in insulin than did glucose – and it promoted different areas of the brain to “light up” in response to the high-calorie food pictures. The orbitofrontal cortex was more active in the fructose group, which the authors say is significant since it’s implicated in reward processing, as was the visual cortex when the participants viewed pictures of food. The hunger and satiety hormones weren’t any different between the two groups. But what was different was the fact that people who’d consumed fructose were much more likely to reject a future monetary reward in favor of a present offering food than were the glucose drinkers. ... "