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" ... This was an easy choice. The new drug of the year is LCZ696, the upcoming heart failure drug from Novartis. At the beginning of the year only a few heart failure experts were aware of it, and no one in the heart failure community or on Wall Street had even suggested that it might be a blockbuster. Expectations, if any, were that the drug would join the long string of recent failures of novel cardiovascular drugs, especially since LCZ696 is a chemical cousin to omipatrilat, the Bristol Myers drug which certainly counts as one of the most spectacular drug failures of all time. ... "