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" ... Or consider the discovery of olanzapine (Zyprexa); it was initially created as part of a deliberate effort to develop a safer version of the drug clozapine, and involved a range of behavioral preclinical paradigms, rather than the sort of highly-specific binding studies generally used today. The result was a molecule that exhibits reasonable binding to a range of receptors rather than exceptional binding to a single receptor. At an award presentation for this molecule (evidently, there are awards for everything), it was noted that “had binding studies been a primary method of selecting compounds, it is unlikely olanzepine would have been developed.” ... "