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" ... The researchers randomized 173 patients with either their first infection or first recurrence to one of four treatment groups: oral liquid formulation of the nontoxigenic strain of C. difficile, NTCD-M3, at a dose of 104 spores/day for 7 days, 107 spores/day for 7 days or 14 days, or placebo. The researchers found they were able to recolonize 71% of the patients with the higher dose of the spores compared to 63% with the lower dose. Recurrent C. diff infection occurred in 30% of placebo patients vs. 11% of the treated patients, with the lowest recurrence (5%) in those who received the higher dose. Only 2% of patients who were successfully colonized became recurrently ill, vs. 31% of those who were not colonized. Also, the need for repeated antibiotic courses reduced from 33% in the placebo group to 14% in patients who were treated with the NTCD-M3 strain. No significant adverse events were seen in this small trial. ... "