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" ... But as treatment for her recurrence ended after she achieved a response, Anna was able to start on maintenance therapy with ZEJULA® (niraparib), leading her eventually to become a patient ambassador for the company that makes it, TESARO. ... "
" ... The NOVA study found that niraparib, given as a daily pill, delays growth of platinum-sensitive tumors in patients with and without inherited (germline) BRCA mutations. For those with germline BRCA mutations, progression-free survival was 21 months with the drug, vs. 5.5 months with placebo. For those without germline BRCA mutations, progression-free survival was 9.3 months vs. 3.9 months. Both findings are highly significant from a statistical perspective. In this trial of niraparib as a single agent, the clinical benefit is clearly greater for those with inherited BRCA mutations. If the investigators were to tease out tumors with acquired mutations, and see if those respond equally or similarly to those with inherited changes, would be more than interesting: it might prove that these drugs don’t "care" where or when the BRCA mutations appear. ... "