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" ... Fate is working toward a class of treatment that is based on NK cells. While the usual process is to create a different batch for each patient from their own stem cells, Fate is intending for mass production of such treatment. The company is currently working on multiple programs, including FT516 for the treatment of acute myeloid leukemia and B-cell lymphoma, FT596 to treat B-cell lymphoma, FT538 to treat AML and multiple myeloma, FT576 to treat multiple myeloma, FT500, FT516, FT-ONO2, and FATE-NK100 for the treatment of advanced solid tumors. It has seen positive findings from early trials for FT500, preventing disease progression for 11 out of 15 patients, something that has kept the stock price buzzing of late. It does make sense given oncology is a high value market and a single drug approval in this space would mean a significant growth in the company’s sales from the $20 million currently. That said, the treatment is still in the very early stages of clinical trials, implying there is still some time before the drug can even move to late stage trials, let alone file for approval subject to a positive outcome of the upcoming studies. And the recent stock price growth means that some of the positives are already priced in at the current price of $114. ... "
" ... In 2009, Evans, who earned an MBA from Wharton and a Masters in biotechnology from the University of Pennsylvania, was an early employee at Agios Pharmaceuticals, then a tiny biotech with a pre-clinical target related to cancer metabolism. The following year he helped broker a unique alliance between Cambridge-based Agios and big biopharma Celgene, ultimately leading to two FDA approvals for treatments for acute myeloid leukemia in the span of ten years, which sounds like a long time, but is much faster than the usual drug development timeline. ... "
" ... The myeloid pathway works differently. Myeloid cells attack the virus and the infected cells directly. Some myeloid cells engulf and destroy virus particles, others kill the infected cells directly, and others still induce a protective inflammatory response by release of compounds called cytokines. ... "
" ... This trial was done in mice with artificial acute myeloid leukemia, but if proven in humans, it is possible it could be expanded to types of leukemia involving other blood cells such as B-cell leukemias, particularly common in children. The speculative cost of this potential new class of therapy is currently unknown, but Gu hopes that it will be close to that of standard PD-1 targeting immunotherapies. ... "
" ... Two of the drug candidates are focused on treating Alzheimer's disease. One targets a triggering receptor on myeloid cells called TREM2. The other targets SIGLEC-3, a transmembrane receptor that's expressed on cells of myeloid lineage. Mutated versions of both TREM2 and SIGLEC-3 are known to contribute to the development and progression of Alzheimer's disease. The other drug candidate targets frontotemporal dementia (FTD), which is a rarer type of dementia but the most common form for people under 60 and typically has an onset age between 45 and 64, according to the Association for Frontotemporal Degeneration. The new funding will pay to bring these drugs into Phase I clinical trials on humans, among other things. (No peer-reviewed research has been published on the company's pre-clinical work yet. Though Alector notes it is currently in the process of submitting its animal model study.) ... "