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" ... But List does see a “major problem” for the Geron drug. Even for high-risk myelofibrosis patients, the condition is chronic. Imetelstat is likely to be given intravenously once a week for three weeks, followed by once every three weeks. With that dosing schedule, it’s going to be very difficult to get patients to stick to the regimen. “If you can get to a more extended schedule it makes a lot more sense,” List says. ... "