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" ... "But the compounds in kratom aren't particularly potent opioids like prescription opioids, morphine or fentanyl. So we started investigating its traditional use from Malaysia where people used it as an opium replacement or to wean themselves off of opium--a different type of methadone or Suboxone (buprenorphine/naloxone) maintenance therapy," says McCurdy. ... "
" ... Cava is consulting to a pharmacy in eastern North Carolina that recently began serving a facility caring for ailing elderly people. The added demand pushed the pharmacy’s orders over the undisclosed threshold so its distributor terminated the supply of morphine for the last twelve days of October. ... "
" ... That summary doesn't mention, however, that Movantik's effectiveness on constipation was only 5% to 15% greater than placebo in its clinical registration trials. But their patient population was highly opioid-tolerant, averaging 140 mg/day morphine equivalents. So, it's pretty impressive that Movantik had that degree of efficacy. ... "
" ... The WHO's Expert Committee on Drug Dependence (ECDD) has recommended that cannabis be deleted from Schedule IV and maintained under less restrictive level of control in Schedule I of the 1961 Convention. Schedule I applies to "harmful psychoactive substances," which could have a medical use such as morphine, as outlined by the WHO. ... "