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" ... The commission said DNA editing technologies could be used in the future to prevent inheritance of monogenic diseases—conditions caused by mutations in one gene—including muscular dystrophy, beta-thalassemia, cystic fibrosis, and Tay-Sachs disease. The Commission defines a serious monogenic disease as one that “causes severe morbidity or premature death,” the report said. But there should be careful assessment to ensure that there are no other unintended genetic changes caused in the process. The report cautioned against the use of DNA editing tools for polygenic diseases, in which multiple genes are involved and several environmental factors could trigger the condition. ... "
" ... We are leaving the largest opportunity for IVF on the table, almost untouched. IVF is a wonderful tool for treating infertility, decreasing the risk for miscarriage, preserving fertility in cancer patients, and facilitating proactive family planning. Active and/or evolving markets exist for each of these indications. But IVF’s greatest potential contribution to medicine, its use for disease prevention using preimplantation genetic diagnosis, is a blip in the reproductive medicine marketplace. Between 4000 and 5000 pregnancies are conceived at risk in the U.S. per year for having a baby with cystic fibrosis. Over 7000 pregnancies are conceived at risk for a baby with sickle cell anemia. Tens of thousands of other pregnancies are conceived with considerable risks for monogenic diseases, in addition to the thousands of pregnancies conceived with no thought to active management of, for example, BRCA status. PGD could prevent all of these diseases—with an IVF procedure that is cheaper, safer and and more effective than methods either in place or in development to treat them. ... "