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" ... Instead, Coles, 54, is using his own money to build a Cambridge, Mass.-based startup called Yumanity that is using yeast, the microbes that help make bread and beer, to study how misfolded proteins in the brain cause Alzheimer's, Lou Gehrig's disease and Parkinson's, and to create drugs based on that knowledge. There's already interest from Big Pharma. Coles says he chose to attack brain diseases, not tumors, because the need is so dire and the science is so fresh. ... "
" ... Proteins play an important role in the health and function of our cells. For example, Alzheimer’s disease is associated with amyloid plaques caused by misfolded Abeta proteins which aggregate together in nerve cells in the brain. So, understanding the location of a protein within a cell is crucial for a variety of medical studies. Scientists from Boston University and the Massachusetts Institute of Technology collaborated with a research team at Brookhaven National Laboratory to demonstrate a new way to image proteins in 3-D at the nanoscale. ... "