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" ... The researchers were finding out more and more, but still hadn't quite finished the puzzle. They delved in further and found that the methotrexate directly activated the microglial cells, creating knock-on effects that upset the function of the astrocytes and oligodendrocytes, leading to the disruption of myelin. The methotrexate had effectively barged in and disrupted a normally-harmonious relationship by causing the normally-peaceful microglial cells to go into overdrive. ... "